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Antiviral Immunity

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Viral infection is a common cause of disease. Outbreak of zoonotic viral diseases such as SARS and Ebola have high mortality rate, as there is a lack of effective prevention and therapeutic measures. Instead, recovery from viral infections often depend on the immune system, which can be divided into adaptive and innate immunity.The innate antiviral immunity in mammalian cells is mediated by interferons, whereby interferon stimulated genes (ISGs) are upregulated to establish an antiviral state. We are interested in interferon-based antiviral response in host cells, particularly in the detection of viral nucleic acids, the modulation of Janus kinase-Signal transducer and activator of transcription (JAK-STAT) signaling pathway, and the role of stress granules in antiviral activity.
Our current research is on interferon regulatory factor 9 (IRF9), which is involved in signaling that results in upregulation of ISGs during type I interferon response. We want to elucidate the mechanism by which IRF9 is regulated during type I interferon response.
*Interested postgraduate candidates are welcomed to apply.

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