BERTAM, July 28, 2017 – RNA-Bio Research group of Infectomic Cluster, IPPT, attended 25th Congress of the Obstetrical & Gynaecological Society of Malaysia, held in Kuala Lumpur recently. IPPT PhD candidate, Ang Kai Cheen, presented her PhD finding in oral presentation entitled “Evaluation of M2/ANXA5 Haplotype as Repeated Spontaneous Abortions Risk Factor in the Malaysian Malay Population”, while their collaborator, Dr Anna Liza Roslani, Obstetrician and Gynaecologist, now at Kuantan Medical Centre, presented a case study entitled “Intervention of Low-Molecular-Weight Heparin in M2/ANXA5 Haplotype Carriers: A Case Report in Pregnancy”.
Repeated Spontaneous Abortions (RSA) is a major topic in reproductive medicine, affecting 1/20 pregnant woman worldwide. It has an adverse psychosocial impact in women and their families. The incidence of RSA is relatively high among the Malay population of Malaysia. Conventional hereditary thrombophilia factors have been generally ruled out. The group evaluated a new predisposition thrombophilia factor, M2/ANXA5 (RPRGL3). The carrier rate of M2/ANXA5 for the general Malay population was 42.2 % with an elevated RSA risk (OR=1.53) specifically for early fetal losses (gestational weeks ≤ 15). Exceeding copy numbers of M2/ANXA5 alleles seemed to contribute a higher risk in RSA couples especially when both partners were M2 carriers. They confirmed the role of M2/ANXA5 as a genetically associated thrombophilia predisposition factor for RSA among ethnic Malay of Malaysia. Dr. Anna Liza presented a case-report study showing that an intervention with low molecular weight heparin (LMWH) could be a successful anticoagulant treatment for M2/ANXA5 carriers with RSA, rendering healthy pregnancy outcome. They proposed the necessary screening of M2/ANXA5 haplotype for two reasons:
1.To assess the risk of having repeated spontaneous abortion
2.It could lead to preventive intervention – anticoagulant (low-molecular-weight-heparin) treatment
Congratulation to Ang KC for wining the best oral presentation in the congress. The project was funded by USM RU grant no: 1001/CIPPT/812100. The financial support from Institute Postgraduate Studies, USM and MyBrain15 program from Ministry of Education were acknowledged.
Repeated Spontaneous Abortions (RSA) is a major topic in reproductive medicine, affecting 1/20 pregnant woman worldwide. It has an adverse psychosocial impact in women and their families. The incidence of RSA is relatively high among the Malay population of Malaysia. Conventional hereditary thrombophilia factors have been generally ruled out. The group evaluated a new predisposition thrombophilia factor, M2/ANXA5 (RPRGL3). The carrier rate of M2/ANXA5 for the general Malay population was 42.2 % with an elevated RSA risk (OR=1.53) specifically for early fetal losses (gestational weeks ≤ 15). Exceeding copy numbers of M2/ANXA5 alleles seemed to contribute a higher risk in RSA couples especially when both partners were M2 carriers. They confirmed the role of M2/ANXA5 as a genetically associated thrombophilia predisposition factor for RSA among ethnic Malay of Malaysia. Dr. Anna Liza presented a case-report study showing that an intervention with low molecular weight heparin (LMWH) could be a successful anticoagulant treatment for M2/ANXA5 carriers with RSA, rendering healthy pregnancy outcome. They proposed the necessary screening of M2/ANXA5 haplotype for two reasons:
1.To assess the risk of having repeated spontaneous abortion
2.It could lead to preventive intervention – anticoagulant (low-molecular-weight-heparin) treatment
Congratulation to Ang KC for wining the best oral presentation in the congress. The project was funded by USM RU grant no: 1001/CIPPT/812100. The financial support from Institute Postgraduate Studies, USM and MyBrain15 program from Ministry of Education were acknowledged.
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