Viral infection is a common cause of disease. Outbreak of zoonotic viral diseases such as SARS and Ebola have high mortality rate , as there is a lack of effective prevention and therapeutic measures. Instead, recovery from viral infections often depend on the immune system, which can be divided into adaptive and innate immunity . The innate antiviral immunity in mammalian cells is mediated by interferons, whereby interferon stimulated genes (ISGs) are upregulated to establish an antiviral state. We are interested in interferon-based antiviral response in host cells, particularly in the detection of viral nucleic acids, the modulation of Janus kinase -Signal transducer and activator of transcription (JAK-STAT) signaling pathway, and the role of stress granules in antiviral activity. Our current research is on interferon regulatory factor 9 (IRF9), which is involved in signaling that results in upregulation of ISGs during type I interferon response. We want to elucidate the mec...